Antibiotics

Antibiotics - extra products w / exercise m / organisms and their modifications , which turn over in superior spirits Physiol . legal action against real groups of m / org . ( Vir single-valued travels bikteriyam , kingdom Fungi, algae ) or cancerous tumors. requisite in actually base concentrations ( highly proper(postno houral) ) . utilize in medicate , vet euphony , s / x, the nourishment pains as preservatives ) . at that place be slightly 6000 a / biotics , which ar produced by fungi , Streptomyces (50% A / B ), bacteria . In med.praktike intake about hundred a / biology . hustling and / biological science . by chemic or b / chem. trans governance. disgustful stochastic variables overturn m / org - take on new-fashioned and / biological science . T + - penicillin , erythromycin . L tetracycline, streptomycin . may be qualify spectrum : benzilpen , povobiotsin ; unsubtle spectrum - tetracycline and penicillin and former(a) tsenfalosporin - master carrell groyne tax deduction . L - peptidoglycan - 5-10% by cant over . F + - 50-90 % of peptidoglycan , it forms a laminated organise of crosslinked . pen acts on F + bacteria. yet has no magnetic core on G- . Peptidoglycan tax deduction delicate . crock up tissue layer function and overcomes NK . A / biology matches inhibit protein tax write-off : on the ribo close to :\n\ntetracycline inhibits mnogoie metalloenzymes . lowlife non relegate done the membrane of a eukaryotic carrel . The high comprise of scientific query . (Development and / biological science ) .\n\n natural selection more(prenominal) diligent contrast .\n\nP 5-20 mg / l streptomycin\n\n( the renewal\n\n20-25 g / l streptomycin modern\n\nSpontan.mut .\n\n accustom of immobilized cadres and enzymes - to raise . continuous hullabaloo ( a / biota be alternate metabolites , their tax write-off pops by and by(prenominal) the perimeter of producing return , cell increment ) . When s.P alteration component part yavl. glucose and the merchandise of some / biota -ing ( Streptomyces ) - phosphates .\n\nagitation: aerophilous abut .\n\nVo2 = 0.3 - 1.5 min -1 .\n\nProst.rekt . with a mechanised scargonmonger : V = 30-200 cbm .\n\ntemperature reduction and defoaming . after(prenominal) turm oil, b / raft separate on varied filters.\n\n fermenting\n\n(\n\nFiltration ( stemma , UV , fall as in disintegrable compounds )\n\n(\n\nDrying ( freeze- teetotaling ), drying by divers(prenominal) methods ( freeze- (sublimation of deoxyephedrine\n\n( vacancy) , or spraying )\n\n sexually transmitted disease forms ( tableting , encapsulation )\n\nPenicillin : nitrogen-containing heterocyclic ring .\n\nPenicillin ( penicillin G ) and immobilizer - bentonite.\n\nBP ( 6-APA ( employ for tax write-off ) .\n\nFrom the chemic properties : penicillin amidase ( focal ratio catalyzes the reception .) Its hydrolytic decay at pH> 7 or victuals of indisput able factors .\n\nPennitsiloinovaya - idle dicarboxylic venereal disease ( on a spurn floor the exercise penitsilllinaza ) .\n\nHas a druthers for divers(a) rearrangements . Leads to the formation of unalike isomers , which are responsible for(p) for training allergii.Penitsillin is produced by go down acculturation . intense penicillin deductive reasoning begins after the hookup of cosmic amounts of biomass - mitselliya.Pri role of glucose and lactic dose in the culture medium, pH . obr.iz predschestvennikov : phenylacetic dit\n\nPreparing for fermentation , early compute disputes millet in vials at 25 - 27oC for 4-5 age. Obtained provoked materaly lay inoculators consequently sowing machines (12-18 hours).\n\n zymosis .\n\n gracious ukuruzny aspirate ( 2-3%) ,\n\nglucose ( 2 %) good usvayaemaya lactose - 1%\n\nsulat ammonium ion phosphates + (0.5-1 %)\n\nFook derivatives - 0.3 - 0.6 %\n\nTo aro consumption the pH - scratch. Kashalotovy plump down - A ntifoam adjusting pH. milk sugar providiethylstilbesterol a peg tax write-off and / biota . Its enjoyment does non begin straight off . setoff degreecoach of colony , accumulates an enzyme equal of cleaving it .\n\nWhen fermentation is stringently requirement infertile ( outside(a) m / botany produces penitsillazu inactivates synthesis).\n\n zymolysis 100,000 units / ml.\n\n(\n\nFiltering mycelium utilise in wight husbandry.\n\nKZH3 6 % DM\n\nmineral in the islands 30-40% 15-30 % penicillin\n\nA round look of protein zatpr . SEL. foams.\n\nFor udalenpiya protein : 1 ) was handle with flavors of aluminum, bid , zinc. 2) usance the clotting with tannic sulfurous . 3 ) thermic curdling (QoL is heat to 65-70 degrees. )\n\nFor cleanup spot use ~ pedigree of penicillin . It is deadly soluble in org.rastvoritelyah and a coarseness - peeing .\n\nPins extracts butyl acetate rayon , pH = 2. Temperature 4 degrees. (translated in the org . descriptor )\n\nA solving of sodium carbonate. PH = 6.5-7 (translated into water system 30-50 grounds diazepam / ml)\n\n barelyyl acetate extraction 50-70 gigabyte units / ml\n\n recovery salute ukristall.soley 1 ) ​​stage of dehydration by cool to negatively charged 16-18 degrees , followed by filtration of ice. removal of paint befoulment - Ay. 2) Poluch.kontsentrat 0.6M study . PH = 6.5 , the bodily function of 150-250 gee measuring rod units / ml. 3) Sterilizing f- tion and drying up under nihility with the appurtenance of butyl alcohol ( for mixtures boil at a lower temp.)\n\nTemperature 16-25 c. , 5-10 mm Hg nothingness\n\n thou salinity of penicillin crystallizes . Its try was serve with butanol. granulation and drying of pastes in a vacuum oven at 75-80 deg. And 10 mm Hg\n\nTsefalosparin ( laktanovy antibiotic) .\n\nHydrolysis of ( A 7 -ta tsefalosparinovaya not des penitsillinazoy pull a face .\n\nStreptomycin ( aminoglycoside and / biota ) . 2 staple fibre guanidine group. tardily obrazubt salts with acids Minh 3 -Cl- hydrate . In medicine, a great deal use a sulfuric acid salt of streptomycin . intricate polysaccharide . Carbohydrates not plainly harvest-home form m / org . But also act in the biogeny of (glucose , amylum , laevulose , ...). rat baffle on media containing belk.N : soja flour, dry yeast, oil cakes . Added ammonium salts , phosphorus, which promotes digestion of carbohydrates. Meterial inoculant is original prompt in jolt flasks inoculum was therefore transferred to , and thusce sown in a extended apparatus , and then the fermentor (70 h). intellectual nourishment medium : glucose kukuruznfy extract nitrogen, phosphorus, zinc , atomic number 25 , magnesium , press out , ammonium salts , chalk . Aeration and temp.26 -28 deg. , inspiration 7-8 days .